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来自加拿大的进口原料

塞可西丁

本品为一种进口的新型合成抗微生物药,是FabH和糖萜素的提纯物(戊糖萜素)混合精制而成。具有很好的抗菌活性和提高机体抗病能力的作用。

作用机理

1传统的抗菌药物大多是干扰细菌体内的氨基酸、核苷酸、氨基糖等小分子的合成,或者是干扰这些小分子合成蛋白质、核酸、肽聚糖等生物大分子的生化过程,而塞可西丁通过抑制细菌脂肪酸生物合成酶,来阻断细菌的脂肪酸合成,从而杀死细菌。

2塞可西丁口服进入机体后对双歧杆菌、乳酸杆菌等微生物的生长有促进作用,而对机体有害的沙门氏菌、大肠杆菌等菌有抑制和杀灭作用,这样就使得肠道内有益菌大量增殖,而胃肠蠕动、增进食欲、促进营养物质的吸收和提高饲料利用率的功能就得到加强。有益菌中的双歧杆菌的细胞壁中含有大量的肽聚糖和磷肽酸物质,具有很强的生物活性,能激活腹腔巨噬细胞、NK细胞和淋巴细胞因子杀伤细胞的活性,从而增强机体的抗病能力。

功能:

1、塞可西丁可有效的治疗大肠杆菌、沙门氏菌等引起的细菌病,对其引起的禽类精神沉郁、羽毛耸乱、拉黄白绿稀粪、包心包肝、心包积水、脐炎、卵黄腹膜炎、肠炎、肠粘膜脱落等症效果显著。

2、塞可西丁可增强机体免疫功能,提高抗病抗应激能力,减少死淘率的作用;对机体内的免疫细胞、血细胞的功能都有很好的增强的作用,其研究结果如下:


淋巴细胞转化率

白细胞活性

免疫球蛋白含量

肾上腺皮质激素

红细胞C3b受体花环率

提高(%

44.69—54.07

32.7—66.09

83.7—115.4

36.44---122.7

21.7P<0.05

应用于动物表现为改善非特异性免疫反应,起到防御病原微生物感染和抗应激作用,从而提高动物的健康状况。同时,可协同增强特异性免疫效果,加强细胞免疫和体液免疫,用于治疗疾病可提高治疗效果,缩短康复时间。

3、塞可西丁可促进蛋白质合成和增强消化酶的活性 ;研究表明,可显著提高血清总蛋白质含量(12.93%)和小肠内消化酶(蛋白质水解酶、脂肪酶和淀粉酶)活性(P<0.05),从而有效改善机体消化吸收功能,促进生长,提高饲料利用率。

应用:

1、我们对多个肉鸡养殖基地进行了流行病学调查、临床症状和病变观察以及细菌学诊断。结果表明:大肠杆菌病的发病率和病死率都很高,从病死鸡中分离出的细菌,通过菌体形态、染色特性、生化试验等系统鉴定,致病菌为大肠杆菌;药敏试验表明,该地区流行的大肠杆菌均呈现多重耐药性。其中塞可西丁的敏感度为最高。药敏试验结果:

药敏纸片

纸片含量(µg

抑菌直径

敏感度

结果判定

塞可西丁

30

33

++

高敏

阿莫西林

25

8

--

耐药

氧氟沙星

30

9

--

耐药

丁胺卡那

30

28

++

高敏

氟苯尼考

30

15

--

中敏

磷霉素钠

50

6

--

耐药

头孢噻肟

30

14

+

中敏

2、塞可西丁绿色无污染,无药残,不易产生耐药性,可用于出口鸡。

 

公司供应电话:15006568779(孙经理)

 

Secxitin

   It is a latest synthetic antimicrobial drug, which is refined from FabH and Saccharicterpenin’s purified material. It has excellent effect on antibacterial activity and improving body resistance.

Mechanism:                                                

1.Traditional antibacterials is mainly combined by hydrones like IFN’s amino acid ,nucleotide and aminosaccharide,or by disturbing the biochemical process those hydrones synthesizing macromolecules such as protein, nuclein, peptidoglycan and so on. However, Secxitin blockades bacterial fatty acid’s composition by stopping bacterial fatty acid biosynthetic enzyme to kill bacterial.

2.Secxitin is taken orally and promote the growth of microbe like Bacillus bifidus and Bacillus acid lactici, but stop or kill the bacterial that is bad for body, like salmonella and e.coli. So probiotics in intestinal tract reproduge in a large number, and enhance the function,such as  gastrointestinal peristalsis, whetting appetite, promoting nutrient intake and improving the utilization rate of forage. Cytoderm of Bacillus bifidus in probiotics has lots of  peptidoglycan and teichoic acid. They have strong biological activity and can activate celiac macrophage, NK cell and lymphocyte factor killing bell to strengthen the body disease resistance.

Function:

1.Secxitin can treat bacteriosis effectively induced by e.coli and salmonella, and has remarkable effect on poultry’s depression, disordered feather, loose yellow white green stools, wrapping heart and liver, hydrocaridia, omphalitis, vitelline peritonitis, enteritis, dropping of intestinal mucosa and etc..

2.Secxitin can improve body’s immune competence, enhance the ability of disease-resistant and anti-stress, reduce mortality and rejection rate. It has great effect on strengthening immunological cell and blood cell. The finding as follows:

   


Lymphocyte’s conversion rate

ACTIVITY OF LEU

Content of immunoglobulin

ACH

wreath rate of RBC C3b

Rate of improvement(%)

44.69—54.07

32.7—66.09

83.7—115.4

36.44—122.7

21.7(P<0.05)

      Applying to animal, Secxitin can ameliorate Nonspecific immune reaction, defense infection of pathogenic microorganism and anti-stress to improve animal’s health. Meanwhile, it can strengthen the affection of specific immunity, strengthen immunity of cell and body fluid. It can improve effect of treatment and reduce rehabilitation time.

3.Secxitin can promote the synthesis of protein and enhance the activity of digestive enzyme. The study indicates, it may improve the content (12.93%) of TSP and the activity (P<0.05) of digestive enzyme (protease, lipase, amylase) in small gut. So Secxitin can improve body’s digestion function, promote growth and raise efficiency of feed utilization.

Application:

 we have made investigation of epidemiology, clinlcal symptom, observation of lesion and bacteriology diagnosis in every poultry base. The result indicates colibacillosis lead to high morbidity and fatality. We find colibacillus is the pathogenic bacterial in the bacteria separated from the dead chicken by systematic identification like morphology of thallus, dyeing property, physiological and biochemical test. The drug sensitive test indicates that colobacillus in this region mainly presents multiple resistance. Secxitin has the highest sensitivity. The result of drug sensitive test as bellow

DRUG

CENTENT

DIAMETER OF BACTERIOSTAT

SENSITIVITY

RESULT

DETECTION

Sexitin

30

33

++

HIGH

Amoxicillin

25

8

--

DRUG  FAST

Ofloxacin

30

9

--

DRUG  FAST

AMK

30

28

++

HIGH

Florfenicol

30

15

--

MIDDLE

FOM Na

50

6

--

DRUG  FAST

Cephalosporin

30

14

+

MIDDLE

2.    Secxitin is a green non-pollution drug, which has no remaining charge and can not produce drug-fast, so it can be applied to export chicken.

 

 

TEL:15006568779  (Mr.  Sun)



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